Food tolerance

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Carbohydrate tolerance and food frequency.

Dietary and pharmacological approaches to slowing the rate of glucose absorption and blunting the insulin response show promise in the treatment of diabetes and hyperlipidaemia. These approaches include dietary fibre, low-glycaemic-index foods and gastrointestinal digestive enzyme inhibitors. One common feature is that they spread the nutrient load over time. A potentially simpler approach is t...

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Specific oral tolerance induction in food allergy.

Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose. Unfortunately, the body of scientific evidence concerning specific oral tolerance induction (SOTI) is still rathe...

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Specific oral tolerance induction for food. A systematic review.

BACKGROUND Specific oral tolerance induction (SOTI) is a new therapeutic approach in the treatment of persistent food allergy. OBJECTIVE The purpose of this article is to systematically review the literature in order to identify, appraise, and synthesize the evidence about SOTI efficacy and safety. METHODS A comprehensive search for citations was conducted on May 2, 2009 using MEDLINE via P...

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Food Allergy , MechanismsOral Tolerance andImmunomodulationTheir Molecular and Cellular

This paper describes the molecular and cellular mechanisms of fbod al]ergy and ora] tolerance including immunomodulation. Food allergy is triggered by an aberrant immune response elicited by ora) administration of dietary antigens. Oral tolerance is a state ef immunological unresponsiveness induced by ora] administration of dietary antigens and is thought to serye to suppress food allergy. This...

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Non-IgE-mediated food allergy: a tolerance induction protocol

Background Cow’s milk proteins allergy (CMPA) is the most common food allergy in childhood, affecting up to 2.5% of infants. The immune mechanisms underlying non-IgE-mediated clinical presentations, which mostly affect the gastrointestinal system and are sometimes very severe, are not fully understood. Currently, specific oral tolerance induction (SOTI) is available as a specific treatment for ...

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ژورنال

عنوان ژورنال: Nature Immunology

سال: 2019

ISSN: 1529-2908,1529-2916

DOI: 10.1038/s41590-019-0431-0